Buildings account for nearly 40% of the end-use energy consumption and carbon emissions globally. Buildings, once built, are used at least for several decades. The building sector therefore holds a significant responsibility for implementing strategies to increase energy efficiency and reduce carbon emissions and thus contribute to global efforts directed toward mitigating the adverse effects of climate change. The work presented in this paper is a part of continuing efforts to identify, analyze and promote the design of low energy, sustainable buildings with special reference to the Kazakhstan locality. Demonstration of improved environmental conditions and impact on energy savings will be outlined through a case study incorporating a passive design approach and detailed computational fluid dynamics analysis for an existing building complex. The influence of orientation and configuration is discussed with reference to energy efficiency and associated wind comfort and safety. The effect of these aspects on energy consumption and comfortable wind environment has been assessed using CFD analysis and proved to be affective. Single building and multiple building configurations have been analyzed and compared. According to the findings, multiple building configurations have better wind conditions when compared with a single standing building. With respect to orientation the former one should be modeled with the fully surrounded side of a “box” opposite to the predominant wind direction whereas the latter one should be located with the rear side opposite to the wind direction. Thus, results indicated that there is a considerable influence of passive design and orientation on energy efficiency, wind comfort and safety. Careful consideration and application of the findings can potentially lead to considerable decrease of energy consumption and, therefore, allow saving money and the environment at the same time.